This paper try to investigate his implication of mind and nature and its relationship through Zhou Ru-deng(Pen name: Haimen)’s doctrine of mind and nature and to examine the effort of mind and nature, practical effort, based on the doctrine of mind and nature. The manifest of innate knowledge as the original substance of mind that Haimen emphasized frequently exposed the distinction and by considering that its induction naturally was made, the innate knowledge has been understood as the moral mind or the nature mind of Humanity). The knowledge of innate knowledge defined as the knowledge of not-knowing which perceived and revealed at all times through the brilliant perception of personality and distinguished the knowledge of experience in the seeing and hearing. As to the original substance of nature, the nature meaned only the heaven-conferred nature of natural nature and not differentiated or not admitted the dispositional nature by integrating the Human Nature as a natural gift and the bodily organs with their functions of all things. In the effort, Haimen integrated the effort for the original substance of mind and the original substance of nature which was the state of having neither the good nor the evil and the effort to preserve the good and remove the evil. Also, the effort to preserve the good and to remove the evil try to solve the problem that aroused from voice and countenance, goods and profit through the effort for the investigation of things and the everyday use including the light Mind, the cultivate stage, the training in actual affairs. Therefore, the effort to preserve the good and to remove the evil including the light Mind is equal to the effort for the doctrine of the extension of knowledge to the investigation of things that tried to recover the natural situation of the original substance of innate knowledge and the original substance of Nature.